Figure 2.

A classification and regression tree (CART) algorithm incorporating Fungitell (1-3)-β-D-Glucan (BDG) and OLM CandID real-time PCR testing for predicting invasive candidiasis (IC) in patients at increased risk of IC (incidence 10%), based on clinical prediction models for candidemia or patients post emergency surgery for intra-abdominal infection or with colonic perforation, as defined by Clancy and Nguyen [9]. The probability of IC is provided together with the 95% interval in parentheses. Sensitivity and specificity values for BDG testing for the diagnosis of IC are comparable with those generated by systematic review and meta-analysis of BDG testing and are in line with those used in previous predictive studies for IC [11,22,23]. Sensitivity and specificity values for CandID are those generated in the prospective arm of this current study when testing serum.