Table 1.
Major characteristics of the included studies.
| No | Study ID [References] | Country | Type of Participants | Disease Condition | Follow-Up Duration | Treatment Strategies | Domperidone + PPI | PPI Alone | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Number of Participants (% Female) | Age of the Participants (Mean ± SD/Range) Years | Number of Participants (% Female) | Age of the Participants (Mean ± SD/Range) Years | |||||||
| 1 | Bediwy 2014 [31] |
Bahrain | Children | Asthma with GERD | 12 weeks | Domperidone 0.5 mg/kg + Esomeprazole 2 mg/kg for 12 weeks | 40 (20) (50%) |
8.1 ± 1.3 | 40 (45%) | 7.7 ± 1.2 |
| 2 | Huiying 2020 [26] |
China | Adult | Asthma with GERD | 1 month | Domperidone 10 mg + Omeprazole 2 × 20 mg for 1 month | 75 (37) (49%) |
55.4 ± 4.5 | 75 (47%) | 55.1 ± 4.2 |
| 3 | Jianzhong 2019 [24] |
China | Children | GERD | 2 months | Domperidone 10 mg + Omeprazole 20 mg for 1 month | 40 (16) (40%) |
2.5 ± 0.2 | 40 (35%) | 2.4 ± 0.1 |
| 4 | Junsuan 2018 [23] |
China | Children | GERD | 8 weeks | Domperidone 3 × (0.3 mg/kg) + IV Omeprazole (0.5–1 mg/kg) for 8 weeks | 30 (12) (40%) |
7.2 ± 1.4 | 30 (50%) | 7.6 ± 1.5 |
| 5 | Marakhouski 2017 [29] |
Belarus | Adult | GERD | 12 weeks | Domperidone 30 mg + Omeprazole 20 mg for 8 weeks | 30 (19) (63%) |
47.1 ± 10.8 | 30 (46%) | 45.7 ± 13.0 |
| 6 | Ndraha 2011 [28] |
Indonesia | Adult | GERD | 2 weeks | Domperidone 3 × 10 mg + omeprazole 2 × 20 mg for 2 weeks | 30 (16) (53%) |
44.3 ± 12.2 | 30 (80%) | 40.4 ± 13.9 |
| 7 | Puranik 2018 [30] |
India | Adult | GERD | 2 weeks | Domperidone 30 mg + Pantoprazole 40 mg for 2 weeks | 40 (12) (30%) |
19.0–78.0 | 40 (30%) | 19.0–78.0 |
| 8 | Shaoxing 2017 [22] |
China | Adult | GERD | 4 weeks | Domperidone 3 × 10 mg + Omeprazole 20 mg for 4 weeks | 34 (14) (41%) |
22.4 ± 1.4 | 34 (35%) | 22.1 ± 1.2 |
| 9 | Taghvei 2019 [32] |
Iran | Adult | GERD | 1 month | Domperidone 3 × 10 mg + Pantoprazole 2 × 40 mg for 1 month | 13 (6) (46.2%) |
35.9 ± 9.9 | 16 (68%) | 37.3 ± 9.2 |
| 10 | Wang 2017 [27] |
China | Adult | Superficial gastritis |
3 weeks | Domperidone 3 × 10 mg + Omeprazole 2 × 20 mg for 3 weeks | 48(27) (56.25%) |
42.7 ± 2.6 | 48 (37%) | 42.8 ± 2.7 |
| 11 | Yajie 2018 [25] |
China | Children | GERD | 2 months | Domperidone 3 × 10 mg + Omeprazole for 2 months | 39 (18) (46%) |
7.1 ± 2.2 | 39 (41%) | 6.9 ± 2.0 |
GERD: gastroesophageal reflux disease, PPI: proton pump inhibitor, IV: intravenous.