Table 1.
Main studies evaluating EOR and RV in patients with GBM.
| Author, Year | Study Type | Patient Population | Conclusion |
|---|---|---|---|
| Lacroix et al., 2001 [8] | Retrospective | 416 patients with GBM | EOR ≥ 98% improved median survival |
| Sanai et al., 2011 [10] | Retrospective | 500 patients with newly diagnosed GBM | EOR ≥ 78% improved OS |
| Oppenlander et al., 2014 [11] | Retrospective | 170 patients with recurrent GBM | EOR ≥ 80% improved OS |
| Bloch et al., 2012 [12] | Retrospective | 107 patients with recurrent GBM | GTR improved OS regardless of initial EOR |
| Lu et al., 2019 [13] | Meta-analysis | 1507 patients with GBM | Maximal resection at reoperation improved OS |
| Chaichana et al., 2014 [14] | Retrospective | 84 patients with newly diagnosed GBM | RV < 2 cm3 and EOR > 95% presented the greatest reduction in the risk of death |
| Orringer et al., 2012 [9] | Retrospective | 46 patients with GBM | EOR ≥ 90% improved 1-year survival |
| Li et al., 2017 [15] | Meta-analysis | 1618 patients with GBM | GTR improved 1-year OS and PFS |
| Grabowski et al., 2014 [16] | Retrospective | 128 patients with newly diagnosed GBM | RV < 2 cm3 and EOR > 98% improved OS |
| Bette et al., 2018 [17] | Retrospective | 209 patients with newly diagnosed GBM | RV was significantly associated with survival |
| Chaichana et al., 2013 [18] | Retrospective | 259 patients with newly diagnosed GBM | RV < 5 cm3 and EOR > 70% improved OS and PFS |
| Woo et al., 2019 [19] | Retrospective (multicenter cohort) | 147 patients with newly diagnosed GBM | MGMT methylation and RV < 3.5 cc improved OS. (EOR was not an independent prognostic factor) |
| Xing et al., 2018 [20] | Retrospective | 292 patients with newly diagnosed GBM | RV, but not EOR, was associated with survival |
| Pessina et al., 2016 [21] | Retrospective | 64 patients with recurrent GBM | RV, but not EOR, was associated with OS and PFS in a multivariate analysis |
| Sales et al., 2019 [22] | Retrospective | 126 patients with newly diagnosed MGMT-unmethylated GBM | RV, but not GTR, improved OS |
| Esquenazi et al., 2017 [23] | Retrospective | 86 patients with newly diagnosed GBM | GTR and near-total resection improved OS |
| Kreth et al., 2013 [24] | Retrospective | 345 patients with newly diagnosed GBM | GTR improved OS; patients who received STR did not show a better OS than those who received biopsy only |
| Shah et al., 2020 [25] | Retrospective | 69 patients with non-eloquent GBM | Supramaximal resection improved OS and PFS compared to matched controls (propensity-matched analysis) |
GBM: glioblastoma; EOR: extent of resection; OS: overall survival; GTR: gross total resection. RV: residual tumor volume; PSF: progression-free survival; MGMT: O-6-methylguanine-DNA-methyltransferase; STR: subtotal resection.