Table 5.

Main studies evaluating the use of IORT in patients with brain tumors.

Author, Year	Study Type	Patient Population	Conclusion
Sakai et al., 1991 [79]	Prospective	73 patients with malignant glioma	IORT improved median survival
Fujiwara et al., 1995 [80]	Prospective	36 patients with glioma	IORT improved median survival
Schueller et al., 2005 [82]	Retrospective	71 patients with malignant glioma	IORT did not improve OS compared to a historical group
Nemoto et al., 2002 [88]	Retrospective	32 patients with malignant glioma	IORT did not improve survival compared to matched control cases
Giordano et al., 2019 [86]	Clinical trial	15 patients with newly diagnosed glioblastoma	IORT was associated with manageable toxicity
Sarria et al. 2020 [89]	Retrospective	51 patients with glioblastoma	Improved efficacy and safety of IORT with low energy X-rays compared to historical data

IORT: intraoperative radiotherapy; OS: overall survival.