Figure 5.

(a) Thioflavin T (ThT) assay for various groups of Aβ₄₂ monomers with NIR laser treatment using PCN−222, PCN-222@ICG excluding photothermal effect (no PT), PCN−222@ICG, and native Aβ₄₂ monomers without nanoprobes. (b) Relative ThT fluorescence signals of various groups at 48 h for native Aβ₄₂ with/without NIR irradiation as control groups, native Aβ₄₂ in the presence of PCN−222 with/without NIR irradiation, and native Aβ₄₂ in the presence of PCN−222@ICG without NIR irradiation, with NIR irradiation, and with NIR irradiation but excluding photothermal effects (no PT). One-way ANOVA with Student’s t-test was used in the analysis. Each experiment had triplicates and was performed three times independently (for above diagrams, NIR laser irradiation is 808 nm with a power density of 0.6 W cm⁻²), *** p<0.001. MALDI-TOF MS spectra of the Aβ₄₂ samples of native Aβ₄₂ monomers (c) without nanoprobe treatment, (d) after treatment with photo-activated PCN−222 excluding photothermal effect, and (e) after treatment with photo-activated PCN−222@ICG.