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(a) Schematic illustration of synthesis of PCN−222@ICG nanoprobe and RVG peptide conjugation and Aβ-induced neurodegeneration, as well as the photo-induced inhibition of Aβ42 aggregation by a hybrid PCN−222@ICG nanoprobe modified with brain-targeting peptide RVG. (b) Fabrication process of brain-on-a-chip and cross-section view of the microfluidic channel. (c) Ex vivo evaluation of NIR-stimulated PCN@ICG for the dissociation of Aβ plaques.
