Figure 5.

Effect of mimic mixtures of MICTs on AHR activity. LS174T-AHR-luc cells were incubated for 4 h with vehicle (DMSO; 0.2% v/v), TCDD (20 nM), and MICTs alone or in the mimic mixture. The concentration of each compound equals the observed mean quantified in human fecal samples [30]. The effects of tested compounds are expressed as a percent of induction of luciferase activity by TCDD over control cells. The experiments were performed in technical quadruplicates and three biological replicates. The error bars represent the mean ± SD, * p < 0.1, ** p < 0.01.