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AHR activation by mimic binary mixtures of IND and IPA. LS174T-AHR-luc cells were incubated for 4 h with vehicle (DMSO; 0.2% v/v), TCDD (20 nM), and the tested compounds alone or in the mixture. Mimic binary mixtures were prepared according to the ratio of IND and IPA that equals the concentration detected in individual aspirates of colonoscopy patients. The experiments were performed in technical quadruplicates and three biological replicates.
