Table 4:

Cluster descriptive statistics of AMD subphenotypes. We group patients into 3 subphenotypes based on their fundus images and sociodemographics up to intermediate AMD stage. Progression time denote the average number of years for patients with AMD to progress from earlier steps (i.e., step 1 and step 4) to later steps (i.e., step 4 and step 9).

	subtype I	subtype II	subtype III
#. of eyes (%)	674 (50%)	380 (28%)	300 (22%)
Late AMD rate (%)	<1%	10%	57%
Enroll age	67.9 ± 4.4	69.5 ± 4.8	70.3 ± 5.3
Male(%)/Female(%)	42%/58%	39%/61%	45%/55%
Smoking history	46%	49%	57%
Depigmentation (%)	9%	31%	38%
Increased pigment (%)	13%	48%	64%
Drusen (%)	78%	97%	99%
Drusen size (micron)	76.1	175.6	197.3
Progression time(S1–S4)	5.6 years	2.8 years	1.9 years
Progression time(S4–S9)	4.9 years	4.7 years	3.6 years