Table 4.

ANOVA test for the dependent variables (particle size, zeta potential, and entrapment efficiency of CUR/LCSNPs).

Source	Sum of Square	Degree of Freedom	Mean Square	F value	p-Value	Remarks
Y1 (nm)
Model-Quadratic	15,323.95	9	1702.66	26.81	0.0001	significant
A-Chitosan	13,464.08	1	13,464.08	211.99	<0.0001
B-Lecithin	9.43	1	9.43	0.1485	0.7114
C-Speed	551.62	1	551.62	8.69	0.0215
AB	71.99	1	71.99	1.13	0.3224
AC	419.86	1	419.86	6.61	0.0369
BC	0.1146	1	0.1146	0.0018	0.9673
A 2	168.61	1	168.61	2.65	0.1473
B 2	272.47	1	272.47	4.29	0.0771
C 2	392.63	1	392.63	6.18	0.0418
Lack of fit	440.16	3	146.72	1.468	0.7217	Not significant
Pure error	4.43	4	1.11
Total correlation	15,768.54	16
Y2 (mV)
Model-Quadratic	489.50	9	54.39	73.82	<0.0001	significant
A-Chitosan	433.65	1	433.65	588.56	<0.0001
B-Lecithin	35.28	1	35.28	47.88	0.0002
C-Speed	0.0012	1	0.0012	0.0017	0.9683
AB	1.44	1	1.44	1.95	0.2048
AC	0.0225	1	0.0225	0.0305	0.8662
BC	0.1600	1	0.1600	0.2172	0.6554
A 2	18.65	1	18.65	25.31	0.0015
B 2	0.2047	1	0.2047	0.2778	0.6144
C 2	0.5026	1	0.5026	0.6822	0.4361
Lack of fit	1.80	3	0.6008	0.7163	0.5918	not significant
Pure error	3.36	4	0.8388
Total correlation	494.66	16
Y3 (%EE)
Model-Quadratic	144.09	9	16.01	20.64	0.0003	significant
A-Chitosan	2.61	1	2.61	3.37	0.1090
B-Lecithin	2.11	1	2.11	2.72	0.1429
C-Speed	21.86	1	21.86	28.18	0.0011
AB	37.45	1	37.45	48.30	0.0002
AC	3.30	1	3.30	4.26	0.0780
BC	2.09	1	2.09	2.69	0.1448
A 2	3.85	1	3.85	4.96	0.0612
B 2	13.00	1	13.00	16.76	0.0046
C 2	52.13	1	52.13	67.22	<0.0001
Lack of fit	3.89	3	1.30	3.37	0.1358	not significant
Pure error	1.54	4	0.3850
Total correlation	149.52	16