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. 2022 Sep 17;14(18):3856. doi: 10.3390/nu14183856

Figure 4.

Figure 4

Leucine protected against aging-induced vascular damage via Sirt1–Foxo1 pathway. Representative Western blot and quantification of vascular leucine transporters Slc3a2 and Slc7a5 from mice at different ages are in (A,B). Representative Western blot and quantification of Sirt1, Foxo1, and acetyl-Foxo1 from mice at different ages are shown in (C,D). Representative Western blot and quantification of vascular Slc3a2 and Slc7a5 from mice in different intervention groups are shown in (E,F). Representative Western blot and quantification of Sirt1, Foxo1, and acetyl-Foxo1 from mice in different intervention groups are shown in (G,H). Statistical analysis was performed using one-way ANOVA; data are presented as mean ± SEM, n = 6/group. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. ND: Normal diet.