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. 2022 Sep 19;23(18):10951. doi: 10.3390/ijms231810951

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schema of the in vitro experiments (A) with the incubation of fluorescence-stained colon cancer cell line (MC38) with different bone marrow-derived macrophages of the wild-type mice, including M0 (incubation with DMEM control media), M1 (LPS activation), M2 (IL-4 stimulation), and tumor-associated macrophages (TAM; using MC38 supernatant), together with whole glucan particle (WGP) or DMEM media control (A), with the characteristics of DMEM- or WGP-activated experiments, as indicated by tumor burdens (fluorescent intensity with the representative pictures) (B,C), genes of M1 macrophage polarization (pro-inflammation) (IL-1β and iNOS) (D,E), and M2 polarization (anti-inflammation) (TGF-β, Arg-1, and Fizz) (F–H). Independent triplicate experiments were performed. *, p < 0.05 vs. DMEM in each group; #, p < 0.05 vs. M0 (DMEM). The picture was generated by BioRender.com.