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. 2022 Aug 30;10(9):1432. doi: 10.3390/vaccines10091432

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Figure A3 — Affinity maturation of the α-syn-specific antibody response after immunization with CW-type 1 and CC-type 1 conjugate vaccines. Investigation of the stability of α-syn-antibody complexes induced two weeks after the second (T2) or two weeks after the third immunization (T3) after challenging with different concentrations of the chaotropic agent sodiumthiocyanate (NaSCN) showing that CW-type 1-induced antibodies are undergoing affinity maturation over the course of all three vaccinations. Residual binding towards α-syn filaments for (A) CW-type 1- and (B) CC-type 1-induced antibodies after challenging with increasing concentrations of chaotropic thiocyanate ions (0.25 M to 3 M). Results of one representative experiment performed in triplicates.