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Dysbiosis scores and correlation with disease severity. (A) Dysbiosis scores across cohorts per country (Wilcoxon test). (B) Correlation between dysbiosis score and disease activity index (Spearman correlation test). rho = 0.031, p = 0.47 for unweighted UniFrac and rho = 0.0056, p = 0.9 for weighted UniFrac of CD (HBI, Harvey Bradshaw index); rho = 0.26, p = 1.8 × 10−7 for unweighted UniFrac and rho = 0.12, p = 0.021 for weighted UniFrac of UC (CAI, colitis activity index).
