Table 2.

Analysis of variance (ANOVA) for 2FI (two factors interaction) model. Term X1 corresponds to the solid lipid concentration, X2 to the liquid lipid concentration, X3 to the surfactant concentration, and X4 to the solid lipid type.

	Y1: Particle Size			Y2: PDI
Source	F-Value	p-Value	Coefficient Estimate	F-Value	p-Value	Coefficient Estimate
Model	18.30	<0.0001	353.86	11.39	<0.0001	0.5433
X1 = solid lipid concn.	16.87	0.0009	−202.06	0.9433	0.3468	0.0194
X2 = liquid lipid concn.	32.81	<0.0001	281.75	0.0134	0.9093	−0.0023
X3 = surfactant concn.	8.36	0.0112	−142.21	17.92	0.0007	0.0844
X4 = solid lipid type	58.22	<0.0001	294.43	61.66	<0.0001	0.1229
X1X2	5.92	0.0279	−169.30	12.25	0.0032	0.0988
X1X3	3.64	0.0757	132.74	0.6361	0.4376	−0.0225
X1X4	13.36	0.0023	−179.78	13.81	0.0021	0.0741
X2X3	1.15	0.3001	−74.66	3.96	0.0652	−0.0561
X2X4	35.42	<0.0001	292.76	0.6686	0.4263	0.0163
X3X4	7.22	0.0169	−132.20	2.05	0.1727	0.0286