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NLC optimization process.
| Factors | Goal | Limits |
|---|---|---|
| Solid lipid concn. (% w/v) | Maximize | 5–10% |
| Lipid liquid concn. (% p/V) | Minimize | 3–6% |
| Surfactant concn. (% w/v) | In range | 1–2% |
| Type of solid lipid | Equal to Softisan® | Softisan® 100, Gelucire® 44/14 |
| Size (nm) | Minimize | 24.21–1960 |
| PDI | Minimize | 0.311–1.000 |
