Table 2.
In-vivo effect of fucoidan on tumor growth in tumor-bearing mice.
| Fucoidan Source | Cancer Cell Type | Action Mechanism | Reference |
|---|---|---|---|
| Cladosiphon okamuranus | Colon 26 | tumor growth↓ | [99] |
| (LMWF) | |||
| IMWF and HMWF | ↑survival time | ||
| Oral administration | ↑NK cells in the spleen | ||
| Fucus vesiculosus | 4T1 Lewis lung cancer cells B16 |
-Inhibition of angiogenesis -Induction of apoptosis -Prevention of metastasis |
[59,78,79] |
| Fucus evanescence | Lewis lung cancer cells | Antitumor and antimetastatic activities | [63] |
| Sargassum plagiophyllum | Diethylnitrosamine-induced hepatocellular | Inhibition of carcinogen metabolism | [100] |
| Cladosiphon okamuranus Tokida | Sarcoma 180 (S-180)-xenograft | ↑cytotoxicity via NO production by fucoidan-stimulated macrophages | [101] |
| Undaria pinnatifida | A20 | Cytolytic activity by Th1 and NK cell activation | [102] |
| Ascophyllum nodosum | MOPC-315 plasma cell tumor | Anti-angiogenesis | [103] |
| Sargassum mcclurei | colon cancer DLD-1 cells | Anti-tumorigenesis | [104] |
| Ecklonia cava | SKOV3 tumor xenograft | -↑ROS-mediated apoptosis -antitumoral |
[105] |
| CT-26 carcinoma xenograft | ↑NK cell-mediated anticancer immunity | [106] | |
| Hydroclathrus clathratus | Sarcoma 180 xenograft | Suppressed tumor growth | [107] |
| Sargassum stenophyllum | B16F10 cells | Antiangiogenic and antitumoral | [108] |
| Stoechospermum marginatum | Ehrlich ascites tumor (EAT) cells | Angio-suppressive and antiproliferative activities | [109] |
| Sargassum fusiforme | A549 | Immunomodulatory activity | [110] |
| SPC-A-1 | Anti-angiogenesis | [111] |