Table 1.

Correlation coefficients from OPLS-DA analysis for significantly changed metabolites in corresponding cells supplemented with SeMet under different Met supply conditions.

No.	Metabolites	Correlation Coefficients
		Model 1 a	Model 2 b	Model 3 c
1	Acetate	0.885	0.883	−0.065
3	Aspartate (Asp)	−0.789	−0.844	−0.933
4	Choline	−0.990	−0.062	−0.051
5	Citrate	−0.491	−0.985	−0.954
6	Creatine	−0.983	−0.964	−0.979
8	Formate	0.708	0.889	0.106
9	Fumarate	0.888	0.345	0.650
10	Glutamate (Glu)	0.961	0.922	0.894
11	Glutamine (Gln)	0.890	0.632	0.389
13	Glycerophosphocholine (GPC)	−0.980	−0.814	−0.629
14	Glycine (Gly)	0.583	−0.737	−0.825
15	Histidine (His)	−0.421	−0.829	−0.736
16	Hypoxanthine	0.045	0.829	0.918
17	Isoleucine (Ile)	0.964	0.928	0.843
18	Lactate	−0.717	−0.901	−0.875
19	Leucine (Leu)	0.979	0.904	0.823
24	NAD	−0.801	−0.342	−0.287
25	Phenylalanine (Phe)	0.983	0.849	0.737
27	Succinate	0.944	0.405	0.162
30	Tryptophan (Trp)	0.844	0.922	0.975
31	Tyrosine (Tyr)	0.977	0.879	0.777
33	UDP-Glucuronate	−0.964	−0.950	−0.948
34	UDP-N-acetylgalactosamine	−0.976	−0.969	−0.950
35	UDP-N-acetylglucosamine	−0.989	−0.944	−0.951
36	Uridine	−0.814	−0.176	−0.062
37	Valine (Val)	0.956	0.925	0.849

^a OPLS-DA model of SeMet supplementation under MR condition (Model 1); ^b OPLS-DA model of SeMet supplementation under adequate Met supply condition (Model 2); ^c OPLS-DA model of SeMet supplementation under abundant Met supply condition (Model 3); correlation coefficient values highlighted in bold (|r| ≥ 0.755) are significant in the model.