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. 2022 Sep 11;23(18):10554. doi: 10.3390/ijms231810554

Figure 5.

Figure 5

BP ameliorates spatial learning and memory in 3xTg AD mice. (A) We have trained the B6 mice and 3xTg mice to find the platforms hidden in the water. Our training time is five days, 90 s each time, once a day. s: second (B) The time spent to reach the platform in each group on Day 1 to Day 5. (C) Time spent in the target quadrant during the test for each group on Day 5. Time spent in the target: B6 mice—vehicle = 14.86 s ± 1.49, 3xTg mice—vehicle = 74.74 s ± 23.83, n = 6; 60 mg/kg BP-treated 3xTg mice = 47.84 s ± 25.69, n = 4; 120 mg/kg BP-treated 3xTg mice = 22.22 s ± 10.14, n = 6; 10 mg/kg treated 3xTg mice = 20.83 s ± 8, n = 4. * p < 0.05. (D) Representative swimming route map of each group on the last day of training. Red dot, the starting point of the swim; green dot, the end point of the swim. The marker of the red circle, yellow triangle, and blue diamond are visual cues.