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. 2022 Sep 14;23(18):10721. doi: 10.3390/ijms231810721

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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¹⁸F-FDG PET/CT axial (left), sagittal (middle) and coronal (right) fused view of right knee in patient no. 2. A first PET/CT scan (lower row) showed the presence of a pathological tissue with high metabolic activity (SUVmax = 26.5) at the level of the right tibia extending to the neighbouring soft-tissue compatible with relapse. A second PET/CT scan performed three months after starting treatment with denosumab (upper row), showed a significant increase in soft-tissue component of the lesion, with stability of FDG uptake. A = anterior; R = right; H = high.