Figure 5.

(A,B) The RXs of the right knee performed at time of initial diagnosis, showed a large, well-defined osteolytic lesion involving the tibial plateau and the proximal third of the tibial shaft, with thinning of the cortical bone. The RX (C,D) of the right leg performed after neoadjuvant treatment with denosumab showed the presence of a lytic alteration of the proximal meta-epiphyseal region with interruption of the cortical bone on the medial aspect of the right tibia; an MRI (E,F) confirmed the present of solid inhomogeneous tissue in the meta-epiphyseal of the tibia with significant involvement of extraskeletal soft tissue.