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(A) Typical histology with osteoclast-like giant cells admixed with mononuclear cells (H&E stain, 20×). (B) Mononuclear cells show immunoreactivity for H3F3A, while the giant cells are negative (20×). (C) Recurrent disease shows different morphological features from the primary neoplasm, with proliferation of an atypical spindle cell population and no evidence of giant cells. (H&E stain, 20×). (D) Neoplastic cells maintain focal positivity for H3F3A immunostaining (20×).
