Table 4.

Quality assesment of in-vitro studies according to QUIN assesment tool.

Criteria No.	Criteria	Kim et al. 2009 [31]	Gracco et al. 2012 [32]	Migliorati et al. 2012 [33]	Migliorati et al. 2013 [34]	Da Cunha et al. 2015 [35]	Walter et al. 2013 [36]	Cha et al. 2015 [37]
1	Clearly stated aims/objectives	2	2	2	2	2	2	2
2	Detailed explanation of sample size calculation	0	0	0	0	2	0	0
3	Detailed explanation of sampling technique	2	2	2	2	1	2	2
4	Details of comparison group	2	2	1	2	2	2	2
5	Detailed explanation of methodology	2	1	1	1	2	2	2
6	Operator details	0	0	1	2	2	2	2
7	Randomization	0	0	0	0	0	0	0
8	Method of measurement of outcome	2	1	2	2	2	1	2
9	Outcome assessor details	1	2	2	2	1	1	1
10	Blinding	0	0	0	0	0	0	0
11	Statistical analysis	2	2	2	2	2	2	2
12	Presentation of results	2	2	1	2	1	1	2
Criteria No.	Criteria	Radwan et al. 2017 [38]	Katić et al. 2017 [39]	Yashwant et al. 2017 [40]	Sana et al. 2020 [41]	Watanbe et al. 2021 [42]	Budasbong et al. 2022 [43]	Redžepagić-Vražalica et al. 2022 [44]
1	Clearly stated aims/objectives	2	2	2	2	2	2	2
2	Detailed explanation of sample size calculation	0	0	0	0	0	0	0
3	Detailed explanation of sampling technique	1	2	1	2	2	2	2
4	Details of comparison group	1	2	1	2	2	2	2
5	Detailed explanation of methodology	1	2	1	1	2	2	1
6	Operator details	1	2	1	2	2	2	0
7	Randomization	0	0	0	0	0	0	0
8	Method of measurement of outcome	2	2	1	2	1	1	2
9	Outcome assessor details	2	2	1	2	2	1	0
10	Blinding	0	0	0	0	0	0	0
11	Statistical analysis	2	2	2	2	2	2	2
12	Presentation of results	1	2	1	2 *—additonally performed FEA does not bring any sigificant information to the study	1	2	2