Table 1.
Summary of the VACV proteins known to be targets of NAbs.
| No. | VACV Protein | Protein Length (VACV) | PDB ID of 3D Structures | Protein Function [46] | MPXV Protein | Similarity (%) | |
|---|---|---|---|---|---|---|---|
| MPXV-CB (Reference Sequence) |
MPXV-2022 (Consensus Sequence) |
||||||
| 1 | A17L | 203 | - | IMV surface membrane protein, early function in virion morphogenesis | A18 | 97.54% | 98.03% |
| 2 | A27L | 110 | 3VOP | IMV surface membrane 14-kDa fusion protein, binds cell surface heparan | A29 | 94.55% | 94.55% |
| 3 | A28L | 146 | - | - | A30 | 96.58% | 96.57% |
| 4 | A33R | 185 | 3K7B | EEV envelope glycoprotein, needed for formation of actin-containing microvilli and cell-to-cell spread | A35 | 96.22% | 95.48% |
| 5 | B5R | 317 | - | Palmitylated 42-kDa EEV glycoprotein required for efficient cell spread, complement control | B6 | 96.53% | 96.53% |
| 6 | D8L | 304 | 4E9O | IMV surface membrane 32 kDa protein, binds cell surface chondroitin sulfate, IMV adsorption to cell surface | E8 | 94.08% | 94.41% |
| 7 | L1R | 250 | 1YPY | Myristylated IMV surface membrane protein | M1 | 98.40% | 98.40% |
| 8 | H3L | 324 | 5EJ0 | IMV heparan-binding surface membrane protein | H3 | 93.83% | 93.83% |