Table 2.
Genetic comparison of known VACV NAb target proteins with corresponding proteins in MPXV-CB and MPXV-2022. The substitutions are computed with reference to the VACV proteins and using the consensus sequence of the ortholog protein for MPXV-2022.
| No. | VACV Protein | Length | Substitutions | ||
|---|---|---|---|---|---|
| Only in MPXV-CB | Only in MPXV-2022 | Common among MPXV-CB and MPXV-2022 | |||
| 1 | A17L | 203 | T183I | - | Y155F, R165K, T171P, V188I |
| 2 | A27L | 110 | - | - | K27N, A30T, D39Y, E40G, V61I, R74H |
| 3 | A28L | 146 | - | - | G23S, Q110R, V130I, V131A, A137T |
| 4 | A33R | 177 | L59Q | E67K, A88V | A73S, Q117K, L118S, S120E, T127A, I141T |
| 5 | B5R | 317 | - | - | Q50S, S55L, I82V, N87D, A166V, M188I, V233I, I236T, T240S, V283M, V296I |
| 6 | D8L | 304 | A19T | - | N18D, P23T, S65T, L66I, L114I, S118A, L124S, T146M, K163T, V181A, D209E, A246V, R253K, T261A, E272G, F293L, R296Q |
| 7 | L1R | 250 | - | - | L51I, K177R, V242I, M248I |
| 8 | H3L | 324 | T111I | A4V | L17P, P44Q, N48D, V51I, K53N, A63V, N74D, N108K, K117N, V124I, M143I, M168I, N171D, L230M, A233S, N251T, A263V, T265A, A274T |