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. 2022 Sep 16;23(18):10846. doi: 10.3390/ijms231810846

Figure 2.

Figure 2

S2R ablation reduces fat mass and increases lean mass in male, but not female, mice fed on HFD. All measurements were performed after 6 weeks of HFD. (A). Legends for (B–G). S2R WT: Tmem97+/+. S2R KO: Tmem97−/−. (B). Body weight. (C). Body composition (% mass vs. total mass). (D). Body composition (mass in grams). (E). Metabolism. Data were normalized to body weight. (F). Respiratory exchange ratio (RER). (G). Heat/EE. Data were normalized to body weight. Each dot (data point, please see the circle, triangle, and square symbols) on the plots represents the area under the curve (AUC) or average (for RER) of each 12-h time period for each individual animal. Statistical analysis: One-way (B–D) or two-way (E–G) ANOVA with Bonferroni’s multiple comparisons test (* p < 0.05, *** p < 0.001), S2R KO vs. WT (the comparison indicated by a red line), n = 10 or 11 mice in (B–D) or n = 4 or 5 mice in (E–G). Data are presented as means ± SE.