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. 2022 Sep 15;14(9):1950. doi: 10.3390/pharmaceutics14091950

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The study of brain AChE inhibition (a) and reactivation (b) in vivo. Mean AChE activity in brain homogenates was measured in a control group of rats (taken as 100%) after poisoning by POX and after injection of free 2-PAM (dose of 2-PAM was 25 mg/kg) and 2-PAM-loaded IA-16/PC liposomes (dose of 2-PAM was 25 mg/kg). Each point represents the mean percent of AChE inhibition in each experimental group. Data presented as mean ± standard error from 5 brain samples; * indicates significant difference by the Mann–Whitney test (p < 0.05) compared with the level of brain AChE inhibition detected 1 hour after POX injection.