Table 1.
Physicochemical characteristics of liposomes based on PC modified by IA-n at various surfactant/lipid molar ratios, hydrocarbon tail length, and storage times: hydrodynamic diameter (DH, nm), polydispersity index (PdI), and zeta potential (ζ, mV), 25 °C.
| System | Surfactant/PC Molar Ratio | 1 Day | 3 Months | ||||
|---|---|---|---|---|---|---|---|
| DH, nm | PdI | ζ, mV | DH, nm | PdI | ζ, mV | ||
| PC | - | 105 ± 2 | 0.205 ± 0.013 | −5 ± 1 | not stable | ||
| IA-10/PC | 0.02/1 | 107 ± 1 | 0.077 ± 0.008 | 22 ± 1 | 118 ± 5 | 0.231 ± 0.024 | 17 ± 1 |
| IA-10/PC | 0.029/1 | 110 ± 1 | 0.068 ± 0.010 | 27 ± 2 | 121 ± 4 | 0.141 ± 0.010 | 25 ± 2 |
| IA-10/PC | 0.04/1 | 107 ± 1 | 0.116 ± 0.010 | 31 ± 1 | 110 ± 2 | 0.099 ± 0.012 | 22 ± 1 |
| IA-12/PC | 0.02/1 | 111 ± 1 | 0.123 ± 0.012 | 27 ± 1 | 118 ± 1 | 0.168 ± 0.015 | 24 ± 1 |
| IA-12/PC | 0.029/1 | 109 ± 2 | 0.106 ± 0.010 | 30 ± 1 | 115 ± 3 | 0.105 ± 0.011 | 42 ± 1 |
| IA-12/PC | 0.04/1 | 107 ± 2 | 0.178 ± 0.015 | 43 ± 2 | 108 ± 1 | 0.184 ± 0.009 | 44 ± 1 |
| IA-14/PC | 0.02/1 | 116 ± 1 | 0.158 ± 0.012 | 45 ± 1 | 109 ± 1 | 0.083 ± 0.006 | 38 ± 2 |
| IA-14/PC | 0.029/1 | 109 ± 1 | 0.129 ± 0.011 | 52 ± 2 | 121 ± 1 | 0.054 ± 0.005 | 49 ± 2 |
| IA-14/PC | 0.04/1 | 109 ± 1 | 0.164 ± 0.010 | 56 ± 1 | 103 ± 1 | 0.081 ± 0.013 | 41 ± 3 |
| IA-16/PC | 0.02/1 | 106 ± 1 | 0.136 ± 0.012 | 41 ± 2 | 107 ± 1 | 0.095 ± 0.016 | 35 ± 2 |
| IA-16/PC | 0.029/1 | 110 ± 2 | 0.134 ± 0.015 | 51 ± 2 | 107 ± 1 | 0.108 ± 0.020 | 56 ± 2 |
| IA-16/PC | 0.04/1 | 112 ± 2 | 0.164 ± 0.010 | 59 ± 1 | 106 ± 1 | 0.123 ± 0.013 | 64 ± 3 |
| IA-18/PC | 0.02/1 | 110 ± 1 | 0.074 ± 0.010 | 43 ± 1 | 108 ± 1 | 0.057 ± 0.024 | 39 ± 1 |
| IA-18/PC | 0.029/1 | 103 ± 1 | 0.068 ± 0.008 | 54 ± 2 | 102 ± 1 | 0.094 ± 0.010 | 56 ± 2 |
| IA-18/PC | 0.04/1 | 107 ± 2 | 0.124 ± 0.010 | 57 ± 1 | 106 ± 1 | 0.077 ± 0.012 | 45 ± 1 |