Skip to main content
. 2022 Sep 15;14(9):1950. doi: 10.3390/pharmaceutics14091950

Table 2.

Physicochemical characteristics of liposomes based on PC modified by IA-n loaded with rhodamine B at various surfactant/lipid molar ratios, IA-n hydrocarbon tail lengths, and storage times: encapsulation efficiency (EE, %), hydrodynamic diameter (DH, nm), polydispersity index (PdI), and zeta potential (ζ, mV), 25 °C.

Rhodamine B
System Surfactant/
PC Molar Ratio
EE,% 1 Day 2 Months
DH, nm PdI ζ, mV DH, nm PdI ζ, mV
PC - 34 ± 1 105 ± 2 0.055 ± 0.002 −3 ± 1 not stable
IA-10/PC 0.02/1 72 ± 1 107 ± 3 0.101 ± 0.026 45 ± 1 111 ± 2 0.075 ± 0.012 31 ± 4
IA-10/PC 0.029/1 72 ± 2 102 ± 2 0.049 ± 0.006 50 ± 1 129 ± 3 0.176 ± 0.014 29 ± 2
IA-10/PC 0.04/1 70 ± 1 101 ± 1 0.073 ± 0.044 60 ± 1 93 ± 3 0.218 ± 0.006 24 ± 1
IA-12/PC 0.02/1 70 ± 1 102 ± 2 0.080 ± 0.017 32 ± 1 116 ± 2 0.183 ± 0.021 23 ± 1
IA-12/PC 0.029/1 69 ± 2 108 ± 2 0.137 ± 0.006 37 ± 1 113 ± 3 0.190 ± 0.033 24 ± 1
IA-12/PC 0.04/1 69 ± 1 101 ± 2 0.088 ± 0.025 48 ± 1 119 ± 1 0.194 ± 0.013 27 ± 1
IA-14/PC 0.02/1 67 ± 3 103 ± 1 0.108 ± 0.008 48 ± 1 112 ± 3 0.089 ± 0.001 23 ± 1
IA-14/PC 0.029/1 69 ± 1 101 ± 2 0.068 ± 0.016 54 ± 1 105 ± 2 0.197 ± 0.034 26 ± 1
IA-14/PC 0.04/1 69 ± 2 102 ± 1 0.082 ± 0.011 57 ± 1 105 ± 1 0.161 ± 0.030 31 ± 3
IA-16/PC 0.02/1 80 ± 1 112 ± 2 0.107 ± 0.039 43 ± 1 121 ± 3 0.211 ± 0.011 21 ± 1
IA-16/PC 0.029/1 81 ± 1 109 ± 1 0.093 ± 0.013 53 ± 1 141 ± 2 0.194 ± 0.100 25 ± 1
IA-16/PC 0.04/1 78 ± 2 104 ± 2 0.179 ± 0.038 65 ± 1 136 ± 1 0.191 ± 0.030 28 ± 3
IA-18/PC 0.02/1 76 ± 1 112 ± 2 0.151 ± 0.007 39 ± 3 138 ± 3 0.193 ± 0.011 22 ± 1
IA-18/PC 0.029/1 77 ± 3 106 ± 2 0.090 ± 0.012 52 ± 1 128 ± 3 0.211 ± 0.011 26 ± 1
IA-18/PC 0.04/1 76 ± 1 105 ± 2 0.086 ± 0.009 59 ± 1 120 ± 3 0.172 ± 0.033 48 ± 1