Table 6.
Quantitative analyses of Fluoro-Jade B labeling in the dentate gyrus, the CA1 and CA3 zones of the hippocampus, and in the entorhinal cortex of mice poisoned by POX and treated with free 2-PAM or liposomal 2-PAM.
| Group | Fluoro-Jade B Positive Cells/mm2 | |||
|---|---|---|---|---|
| Dentate Gyrus | CA1 | CA3 | Entorhinal Cortex | |
| Control | 2.71 ± 0.27 | 2.28 ± 0.29 | 1.89 ± 0.23 | 1.78 ± 0.18 |
| Free 2-PAM (25 mg/kg, i.v.) + POX (2 mg/kg, s.c.) |
12.46 ± 1.6 *** | 17.27 ± 1.76 *** | 9.77 ± 1.17 *** | 10.48 ± 0.69 *** |
| Liposomal 2-PAM (25 mg/kg, i.v.) + POX (2 mg/kg, s.c.) | 4.75 ± 0.46 **# | 7.68 ± 0.91 ***# | 9.2 ± 0.91 *** | 9.09 ± 0.57 *** |
Data represent the mean value ± SEM from 48 brain sections in each group. ** p < 0.01, *** p < 0.001 compared with the control group; # p < 0.05 compared with the group treated with free 2-PAM. Statistical analysis was performed using the Mann-Whitney test.