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. 2022 Aug 25;14(9):1776. doi: 10.3390/pharmaceutics14091776

Figure 1.

Figure 1

Inhibitory effect of ATR-002, MPV, RDV, NTV and RTV on SARS-CoV-2 replication. Calu-3 cells were infected with SARS-CoV-2 (D614G) (MOI: 0.01). One h.p.i. drug treatment was initiated. Untreated (SARS-CoV-2) and DMSO-treated cells served as negative controls. Viral titers were analyzed 48 h.p.i. (a,c,e,g,i). Viral titers in % of DMSO. DMSO was arbitrarily set to 100%. Shown are means ± SEM of five independent experiments, each performed in triplicates. Significance was calculated by one-way ANOVA in combination with a Dunnett’s multiple comparisons test using DMSO as reference (** p ≤ 0.0021; **** p ≤ 0.0001) (see also Figure S1). (b,d,f,h,j) Calculation of the EC values.