Protection of 3HP-β-LG against influenza virus infection in mice. (A,B) Prophylactic protection of 3HP-β-LG against influenza virus infection in mice treated with 3HP-β-LG 0.5 h before challenge with A(H1N1)/PR8, A(H3N2), or A(H7N9). (A) Bodyweight change (%) and (B) survival rate (%) of mice were recorded daily post-infection. *, **, and *** denote p < 0.05, 0.01, and 0.001, respectively. (C,D) Therapeutic protection of 3HP-β-LG against influenza virus infection in mice 4 h after challenge with A(H1N1)/PR8, A(H3N2), and A(H7N9). (C) Bodyweight change (%) and (D) survival rate of mice were recorded daily post-infection. Data are presented as mean ± SD.