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. 2022 Sep 9;13:968755. doi: 10.3389/fimmu.2022.968755

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Copyright © 2022 Chen, Cao, Wang, Chu, Li, Hou, Zheng, Li and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The emerging roles TRIM21 in coordinating cancer metabolism, immunity and cancer treatment. TRIM21 acts at multiple nodes to control cancer metabolic reprogramming inhibiting the increased metabolic demands of malignancy including glycolysis, fatty acids metabolism and branched-chain amino acid metabolism. TRIM21-mediated metabolic regulation not only indirectly effects immune cell infiltration, but also cross-talks innate immunity and adaptive immune directly, takes part in balancing immune response. TRIM21 also has indispensable roles in mediating cancer therapeutic effects, playing a decisive role in the fate of cancer.TRIM21 has tremendous application potential in cancer diagnosis, treatment and prognosis.