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. 2022 Sep 23;8(38):eabq0304. doi: 10.1126/sciadv.abq0304

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Fig. 5. — (A) Phylogenetic reconstruction of MetX proteins: MetX-G1 in blue, MetX-G2 in yellow, MetX-G3a in green, MetX-G3b in brown, MetX-G3c in red, and MetA as the outgroup in gray. Each group has its enzymatic activity in parenthesis: HAT, HST, and SST. A. loripes putative Cys2 (Acys2) and S. pombe Cys2 are denoted by an asterisk (*). Acys2 was classified as a MetX-3Gc SST together with animal sequences from all lineages except for vertebrates, arthropods, and nematodes. The phylogenetic tree was generated with IQ-TREE and visualized with iTOL. (B) Identification of important residues in putative Cys2 protein sequences for SST activity. MetX-G3c in red, MetX-G3a in green, and MetX-G3b in brown. Important residues for an SST activity are highlighted in gray. A. loripes Cys2 and other eukaryotic putative Cys2 proteins have all the required residues for SST activity.