Table 4.

Multivariate analysis: MRD values measured by RQ-PCR in BM as MRD kinetics

	TTP
Variables	HR	95% CI	P value
MIPI intermediate vs low	0.68	(0.241-1.99)	.5
MIPI high vs low	0.78	(0.26-2.36)	.7
Ki67 ≥30%	2.27	(0.92-5.61)	.075
PR after ASCT	4.74	(1.02-21.9)	.046
Alternating MRD after ASCT (vs persistently MRD NEG after ASCT, M6 and M12)	5.51	(2.02-15.0)	<.001
Persistently MRD POS after ASCT (vs persistently MRD NEG after ASCT, M6 and M12)	6.93	(1.74-27.6)	.006

M6, 6 months from transplant; M12, 12 months from transplant; MRD NEG, negative minimal residual disease; MRD POS, positive minimal residual disease; PR, partial response.

78 randomized patients, landmark analysis starting from 12 months from transplant.