Table 2.
Proportions of Shigella isolates from the Andaman Islands resistant to various antibacterial drugs during 2000–2005 and 2006–2011 and statistical significance of the difference (χ2 test)
| Antimicrobial agents | Resistance | P value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2006–2011 | 2000–2005 | ||||||||||
| S. flexneri (N = 55) | S. sonnei (N = 23) | S. dysenteriae (N = 8) | S. boydii (N = 2) | All Shigella isolates (N = 88) | S. flexneri (N = 33) | S. sonnei (N = 32) | S. dysenteriae (N = 3) | S. boydii (N = 6) | All Shigella isolates (N = 74) | ||
| Ampicillin | 100·0 (55) | 100·0 (23) | 100·0 (8) | 100·0 (2) | 100·0 (88) | 51·5 (17) | 37·5 (12) | 66·7 (2) | 50·0 (3) | 45·9 (34) | <0·05 |
| Nalidixic acid | 96·4 (53) | 100·0 (23) | 87·5 (7) | 100·0 (2) | 96·6 (85) | 45·5 (15) | 100·0 (32) | 33·3 (1) | 0 | 64·9 (48) | 0.000002 |
| Tetracycline | 94·5 (52) | 82·6 (19) | 100·0 (8) | 100·0 (2) | 92·0 (81) | 51·5 (17) | 68·8 (22) | 66·7 (2) | 0 | 55·4 (41) | 0.000001 |
| Norfloxacin | 87·3 (48) | 73·9 (17) | 75·0 (6) | 50·0 (1) | 81·8 (72) | 0 | 6·3 (2) | 33·3 (1) | 0 | 4·1 (3) | <0·05 |
| Co-trimoxazole | 74·5 (41) | 91·3 (21) | 75·0 (6) | 100·0 (2) | 79·5 (70) | 81·8 (27) | 100·0 (32) | 66·7 (2) | 16·7 (1) | 83·7 (62) | 0·625018 |
| Ciprofloxacin | 76·4 (42) | 73·9 (17) | 87·5 (7) | 50·0 (1) | 76·1 (67) | 0 | 6·3 (2) | 33·3 (1) | 0 | 4·1 (3) | <0·05 |
| Ofloxacin | 74·5 (41) | 65·2 (15) | 75·0 (6) | 50·0 (1) | 71·6 (63) | 0 | 0 | 0 | 0 | 0·0 (0) | <0·05 |
| Carbenicillin | 74·5 (41) | 21·7 (5) | 75·0 (6) | 50·0 (1) | 60·2 (53) | 0 | 0 | 0 | 0 | 0·0 (0) | <0·05 |
| Azithromycin | 29·1 (16) | 78·3 (18) | 87·5 (7) | 100·0 (2) | 48·8 (43) | 0 | 0 | 0 | 0 | 0·0 (0) | <0·05 |
| Amikacin | 29·1 (16) | 52·2 (12) | 62·5 (5) | 50·0 (1) | 38·6 (34) | 0 | 0 | 0 | 0 | 0·0 (0) | <0·05 |
| Gatifloxacin | 29·1 (16) | 47·8 (11) | 75·0 (6) | 50·0 (1) | 38·6 (34) | 0 | 0 | 0 | 0 | 0·0 (0) | <0·05 |
| Cephalothin (cephalexin) | 36·4 (20) | 34·8 (8) | 62·5 (5) | 50·0 (1) | 38·6 (34) | 0 | 0 | 0 | 0 | 0·0 (0) | <0·05 |
| Chloramphenicol | 41·8 (23) | 4·3 (1) | 37·5 (3) | 00·0 (0) | 30·6 (27) | 36·4 (12) | 03·1 (1) | 33·3 (1) | 0 | 18·9 (14) | 0·125047 |
| Cefuroxime | 25·5 (14) | 8·7 (2) | 50·0 (4) | 50·0 (1) | 23·8 (21) | 0 | 0 | 0 | 0 | 0·0 (0) | 0·000002 |
| Gentamicin | 21·8 (12) | 13·0 (3) | 25·0 (2) | 100·0 (2) | 21·5 (19) | 0 | 0 | 0 | 0 | 0·0 (0) | 0·000062 |
| Cefixime | 16·4 (9) | 8·7 (2) | 37·5 (3) | 50·0 (1) | 17·0 (15) | 0 | 0 | 0 | 0 | 0·0 (0) | 0·000548 |
| Ceftriaxone | 16·4 (9) | 8·7 (2) | 37·5 (3) | 50·0 (1) | 17·0 (15) | 0 | 0 | 0 | 0 | 0·0 (0) | 0·000548 |
| Cefotaxime | 16·4 (9) | 8·7 (2) | 37·5 (3) | 50·0 (1) | 17·0 (15) | 0 | 0 | 0 | 0 | 0·0 (0) | 0·000548 |
| Ceftazidime | 16·4 (9) | 8·7 (2) | 37·5 (3) | 50·0 (1) | 17·0 (15) | 0 | 0 | 0 | 0 | 0·0 (0) | 0·000548 |
| Amoxicillin-clavulanic acid (augmentin) | 16·4 (9) | 8·7 (2) | 37·5 (3) | 50·0 (1) | 17·0 (15) | 0 | 0 | 0 | 0 | 0·0 (0) | 0·000548 |
| Nitrofurantoin | 7·3 (4) | 4·3 (1) | 37·5 (3) | 50·0 (1) | 10·2 (9) | 0 | 6·3 (2) | 0 | 0 | 2·7 (2) | 0·113457 |
| Imipenem | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 (0·0) | |
Values given are % (n).