Table 2.
Detailed Characteristics of Participants Included in the Present Studies (Experimental and Control Groups)
| Study Design | Participants | Age | Intervention | Comparison | OM Grade | Country | Reference |
|---|---|---|---|---|---|---|---|
| Randomised controlled pilot study | n=33 (F) n=57 (M) |
≥2 to ≤18Y | Nature honey/HOPE (routine oral care) | Benzocaine 7.5% gel (routine oral care) | II and III | Egypt | Abdulrhman et al, 201227 |
| Quasi-experimental study with a control group | n=38 (F) n=38 (M) |
≥6 to ≤17Y | Natural and standardized flower honey (routine and standard mouth care) | Routine mouth care | No OM/all grades | Turkey | Bulut and Tüfekci, 201626 |
| RCT | n=16 (F) n=24 (M) |
≥5 to ≤19Y | Honey and tulsi ice chips | Plain ice cubes | No OM | India | Mishra and Nayak, 201729 |
| Open-label RCT | n=19 (F) n=21 (M) |
≥1Y | Local Saudi commercial honey (routine oral hygiene) | Routine oral hygiene (Lidocaine, Mycostatin, Daktarin mouth gel, and mouthwash) | III and IV | Saudi Arabia | Al Jaouni et al, 201728 |
| Observational blind design | n=100 (N/D) | N/D | Commercially available marketed honey product (the routine practice of analgesic and antiseptic gel) | The routine practice of analgesic and antiseptic gel application | I and II | India | Singh et al, 201912 |
Abbreviations: RCT, randomised controlled trial; n, the number of participants; N/D, not detected; F, female; M, male; OM, oral mucositis.