Table 2.
Clinical Characteristics Between Acute and Chronic Brucellosis in Beijing Youan Hospital Between 2010 and 2021
| Variable | Acute (n=165) | Chronic (n=32) | p value |
|---|---|---|---|
| Symptoms and signs, n (%) | |||
| Fever | 140 (84.8%) | 23 (71.9%) | 0.076 |
| Arthralgia | 103 (62.4%) | 26 (81.3%) | 0.040 |
| Hyperhidrosis | 71 (43.0%) | 16 (50.0%) | 0.467 |
| Fatigue | 65 (39.4%) | 15 (46.9%) | 0.430 |
| Weight loss | 45 (27.3%) | 8 (25.0%) | 0.791 |
| Myalgia | 33 (20.0%) | 6 (18.8%) | 0.087 |
| Chills | 43 (26.1%) | 3 (9.4%) | 0.041 |
| Headache | 21 (12.7%) | 3 (9.4%) | 0.772 |
| Splenomegaly | 40 (24.2%) | 1 (3.1%) | 0.007 |
| Enlarged lymph nodes | 9 (5.5%) | 1 (3.1%) | 1.000 |
| Rashes | 8 (4.8%) | 2 (6.3%) | 0.667 |
| Digestive system disordersa | 36 (21.8%) | 4 (12.5%) | 0.230 |
| Respiratory disordersb | 29 (18.8%) | 2 (6.5%) | 0.107 |
| Laboratory findings | |||
| ESR (mm/h), median (IQR) | 25.0 (10.0–45) | 21.5 (6.0–37.5) | 0.254 |
| CRP (mg/L), median (IQR) | 20.0 (6.9–40.8) | 10.8 (1.0–31.3) | 0.084 |
| Leukocyte (×109/L), median (IQR) | 5.7 (4.2–7.4) | 6.8 (4.3–8.3) | 0.190 |
| Lymphocyte (×109/L), median (IQR) | 2.0 (1.4–2.8) | 2.0 (1.6–2.7) | 0.895 |
| Neutrophils (×109/L), median (IQR) | 2.6 (2.0–4.1) | 3.7 (2.3–5.0) | 0.060 |
| Monocyte (×109/L), median (IQR) | 0.4 (0.3–0.6) | 0.4 (0.3–0.6) | 0.688 |
| Hemoglobin (g/L), mean ± SD | 119.8 ± 19.3 | 127.3 ± 19.1 | 0.047 |
| Albumin (g/L) | 36.4 ± 4.8 | 38.4 ± 4.5 | 0.019 |
| Platelet count (×109/L), median (IQR) | 211.5 (150.0–281.0) | 218 (181.2–278.2) | 0.462 |
| ALT (U/L), median (IQR) | 37.1 (23.5–65.2) | 20.3 (12.8–35.0) | <0.001 |
| AST (U/L), median (IQR) | 37.2 (23.9–63.6) | 20.8 (16.8–31.4) | <0.001 |
| TBIL (μmol/L), median (IQR) | 12.6 (8.8–19.7) | 11.0 (7.7–16.9) | 0.366 |
| Creatinine (μmol/L), median (IQR) | 57.8 (45.0–67.6) | 59.6 (53.9–67.6) | 0.237 |
| Focal involvement, n (%) | 64 (38.8%) | 12 (37.5%) | 1.000 |
| Peripheral arthritis | 14 (8.5%) | 2 (6.3%) | 1.000 |
| Spondylitis | 28 (17.0%) | 8 (25.0%) | 0.282 |
| Epididymoorchitis | 16 (9.7%) | 1 (3.1%) | 0.317 |
| Meningitis | 8 (4.8%) | 0 (0.0%) | 0.358 |
| Endocarditis | 2 (1.2%) | 1 (3.1%) | 0.414 |
Notes: Bold values denote statistically significant differences (p < 0.05). aDigestive system disorders include anorexia, vomiting and abdominal pain. bRespiratory disorders include pneumonia and pleural effusions.
Abbreviations: SD, standard deviation; IQR, interquartile range; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin.