Table 2.
Gastric healing activity induced by chitosan (C) and derivatives thereof modified with acetylacetone (Cac), ethylenediamine (Cacen), and diethylenetriamine (Cacdien) after treatment at daily doses of 80 mg/kg for seven days on acetic acid-induced gastric ulcer in rats.
| Samples (groups) | Ulcer volume (mm3) | Gastroprotective activity (%) |
|---|---|---|
| Vehicle∗ | 190.3 ± 25.4 | 0.0 |
| Chitosan | 93.6 ± 35.5 | 50.7 |
| Cac | 155.3 ± 21.5 | 18.4 |
| Cacen | 85.3 ± 18.0 | 55.2 |
| Cacdien | 60.8 ± 28.7 | 68.1 |
| Cimetidine (100 mg/kg) | 43.9 ± 10.2 | 76.9 |
The results are expressed as gastric ulcer volume ± standard error of the mean. One-way ANOVA followed Tukey's post hoc test. Differences were considered significant when p < 0.05. ∗Injured control group (without treatment).