Table 4.
Multivariate regression models of the sub-distribution hazards of immunodeficiency-related death, considering other deaths as competing event in 2372 PLWH, 2007–2012
| Saturated multivariate model | Final multivariate model | |||||
|---|---|---|---|---|---|---|
| (n = 2372) | (n = 2372) | |||||
| Variables | SHR | (95% CI) | P value | SHR | (95% CI) | P value |
| Sociodemographic and life habits variables | ||||||
| Sex | ||||||
| Female | 1·00 | |||||
| Male | 0·91 | (0·67–1·24) | 0·567 | |||
| Age group, years | ||||||
| 17–39 | 1·00 | |||||
| ⩾40 | 0·88 | (0·66–1·18) | 0·400 | |||
| Literacy | ||||||
| Yes | 1·00 | |||||
| No | 1·27 | (0·88–1·82) | 0·205 | |||
| Monthly individual income | ||||||
| ⩾1 Minimum salary | 1·00 | |||||
| <1 Minimum salary | 0·81 | (0·61–1·08) | 0·161 | |||
| Smoking | ||||||
| Never smoked | 1·00 | |||||
| Current smoker | 1·40 | (1·00–1·96) | 0·051 | |||
| Ex-smoker for ⩾6 months | 0·99 | (0·69–1·42) | 0·948 | |||
| Illicit drugs | ||||||
| Never used | 1·00 | |||||
| Used at some point | 1·13 | (0·83–1·52) | 0·437 | |||
| Alcohol | ||||||
| Non-drinker | 1·00 | 1·00 | ||||
| Light drinker | 0·60 | (0·41–0·90) | 0·012 | 0·66 | (0·45–0·98) | 0·038 |
| Excessive drinker | 0·58 | (0·37–0·90) | 0·016 | 0·68 | (0·45–1·05) | 0·080 |
| In work | ||||||
| Yes | 1·00 | 1·00 | ||||
| No | 1·47 | (0·99–2·19) | 0·056 | 1·56 | (1·05–2·32) | 0·027 |
| Clinical variables | ||||||
| CD4 cell count at baseline | ||||||
| ⩾200 cells/mm3 | 1·00 | 1·00 | ||||
| 1–199 cells/mm3 | 3·52 | (2·45–5·07) | 0·000 | 3·33 | (2·35–4·74) | 0·000 |
| Not informed | 4·63 | (3·26–6·58) | 0·000 | 4·63 | (3·31–6·48) | 0·000 |
| Anaemia at baseline | ||||||
| No | 1·00 | 1·00 | ||||
| Yes | 3·62 | (2·51–5·23) | 0·000 | 3·58 | (2·49–5·14) | 0·000 |
| Not informed | 5·75 | (3·69–8·97) | 0·000 | 5·93 | (3·85–9·14) | 0·000 |
| Nutritional status at baseline | ||||||
| Normal | 1·00 | 1·00 | ||||
| Underweight | 1·18 | (0·81–1·72) | 0·399 | 1·16 | (0·78–1·69) | 0·433 |
| Overweight | 0·67 | (0·45–1·01) | 0·054 | 0·64 | (0·43–0·95) | 0·029 |
| Treatment for TB during the cohort | ||||||
| No | 1·00 | 1·00 | ||||
| Yes | 3·85 | (2·80–5·29) | 0·000 | 4·01 | (2·95–5·44) | 0·000 |
| Chemoprophylaxis for TB during the cohort | ||||||
| Not indicated and not treated for LTBI | 1·00 | |||||
| Indicated and treated for LTBI | 0·95 | (0·38–2·40) | 0·922 | |||
| Indicated and not treated for LTBI | 0·89 | (0·47–1·69) | 0·729 | |||
| No tuberculin skin test | 0·97 | (0·70–1·35) | 0·849 | |||
PLWH, People living with HIV/AIDS; SHR, sub-distribution hazard ratio; CI, confidence interval; LTBI, latent tuberculosis infection.
Mean values in dollars for Brazilian minimum salary: US$185.64 (2007); US$246.88 (2008); US$198.13 (2009); US$295.82 (2010); US$327.92 (2011); US$332.98 (2012);