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. 2022 Sep 9;13:981206. doi: 10.3389/fphar.2022.981206

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Copyright © 2022 Li, Wang, Qi, Yuan, Lv, Zheng, Yan, Wang, Fu, Fan, Ji, Liu and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI network construction, metabolite-target-GO and metabolite-target-KEGG pathway interaction networks. (A): PPI network comprised 46 nodes and 369 edges. The nodes suggested targets, the edges indicated the interactions between the nodes, and the size of the nodes represented the value of the degree. The key targets of QSYQ in the treatment of myocardial I/R injury included AKT1, Bcl-2, Caspase-1, GSK-3β, p53, etc., (B): Metabolite-target-GO interaction network; (C): Metabolite-target-KEGG pathway interaction network.