Table 1.
The top ten significantly associated genes observed in the schizophrenia and substance dependence (AD, CUD, ND, and OD) MAGMA meta-analyses that were nominally significant (P < 0.05) in the individual GWAS but did not pass multiple-testing corrections.
| Gene symbol | PSZ | PSUD | PMETA |
|---|---|---|---|
| MED27 | 6.47 × 10−5 | ND, 1.425 × 10−5 | SZ + ND, 8.64 × 10−9 |
| BDNF | 4.22 × 10−6 | AD, 1.08 × 10−2 | SZ + AD, 2.75 × 10−7 |
| CUD, 1.39 × 10−4 | SZ + CUD, 3.42 × 10−8 | ||
| IZUMO1 | 2.29 × 10−5 | AD, 6.52 × 10−3 | SZ + AD, 1.05 × 10−6 |
| CUD, 1.13 × 10−4 | SZ + CUD, 7.67 × 10−8 | ||
| HYAL3 | 2.06 × 10−5 | CUD, 1.47 × 10−4 | SZ + CUD, 9.83 × 10−8 |
| HMGN4 | 3.65 × 10−4 | CUD, 2.63 × 10−5 | SZ + CUD, 1.00 × 10−7 |
| EP300 | 1.18 × 10−5 | AD, 9.72 × 10−4 | SZ + AD, 1.36 × 10−7 |
| SPECC1 | 8.28 × 10−6 | AD, 1.99 × 10−3 | SZ + AD, 1.51 × 10−7 |
| PPP2R2A | 2.95 × 10−6 | OD, 9.82 × 10−3 | SZ + OD, 1.78 × 10−7 |
| MED19 | 1.16 × 10−5 | AD, 2.82 × 10−2 | SZ + AD, 1.74 × 10−6 |
| CUD, 3.53 × 10−4 | SZ + CUD, 2.01 × 10−7 | ||
| OD, 3.25 × 10−2 | SZ + OD,, 1.99 × 10−6 | ||
| FUT2 | 3.37 × 10−6 | AD, 1.02 × 10−2 | SZ + AD, 2.10 × 10−7 |
| CUD, 4.18 × 10−3 | SZ + CUD, 2.55 × 10−6 |