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. 2022 Sep 23;12:15900. doi: 10.1038/s41598-022-19438-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Peak isometric force is reduced following an eccentric contraction-induced injury protocol. (A) Peak isometric force of EDL muscles from Sham and OVX mice did not differ before (Pre) or after (Post) contractions. (B) Peak isometric force of EDL muscle with and without skeletal muscle estrogen receptor α (ERα) immediately before (Pre) and after (Post) a bout of 10 maximal, high force eccentric contractions was lower in ERα-cKO. Following the last contraction, the Krebs buffer surrounding each muscle was collected as the conditioned media and used in the in vitro bone cell assays. *Significantly different from ERα-cKO.