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. 2022 Sep 23;12:15900. doi: 10.1038/s41598-022-19438-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ERα-cKO mice have enhanced osteoclasts. (A–C) Bone marrow macrophages from ERα-WT and ERα-cKO animals were treated with M-CSF and RANKL to induce osteoclast differentiation. (A) average number and (B) average size of TRAP positive multinuclear cells and (C) average size of demineralized area. (D) Mesenchymal bone marrow cells were grown to confluency and induced to differentiate with the addition of ascorbic acid. Von Kossa assay was performed to measure percent mineralization of mesenchymal cells from ERα-WT and ERα-cKO animals. *Significantly different from ERα-WT.