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. 2022 Sep 23;12:15893. doi: 10.1038/s41598-022-20217-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analyzing classification of subgroups based on nonnegative matrix factorization (NMF) cluster. (A) NMF divides the expressed values into two subgroups of matrices. (B) Survival curve of the patients based on two clusters. (C) Stromal score, immune score, ESTIMATE score and tumor purity compared by the two clusters. (D) Assess the proportion of inflammatory cells by CIBERSORT. (E) Inflammatory cell infiltration analysis by CIBERSORT.