Table 2.

Number of subjects identified by each proposed algorithm as having acromegaly (cases) in Caserta Local Health Unit (period January 2015–December 2018) and in Sicily Region (period January 2011–December 2018). CI = confidence interval calculated using the exact Clopper–Pearson method for a binomial proportion.

	Algorithm 1	Algorithm 2	Algorithm 3	Algorithm 4
Caserta local health unit (study period: 2015–2018)
N. identified cases/total population	84/1,060,904	92/1,060,904	116/1,060,904	146/1,060,904
N. identified cases per 100,000 inhabitants (95% CI)	7.9 (6.4–9.8)	8.7 (7.1–10.6)	11.0 (9.1–13.1)	13.8 (11.7–16.2)
Sicily region (study period: 2011–2018)
N. identified cases/total population	394/5,031,655	533/5,031,655	768/5,031,655	824/5,031,655
N. identified cases per 100,000 inhabitants (95% CI)	7.8 (7.1–8.6)	10.6 (9.7–11.5)	15.3 (14.2–16.4)	16.4 (15.3–17.5)