Table 3.
Odds ratio of late-onset sepsis per causing pathogen between different duration of early empiric antibiotic exposure
| OR [95%CI] | p-value |
Adjusted ORa [95%CI] |
p-value | |
|---|---|---|---|---|
| NEC | ||||
| Any EEAE vs. non-EEAE | 0.85 [0.46–1.57] | 0.61 | 0.47 [0.23–0.96] | 0.04* |
| Short EEAE vs. no EEAE | 0.70 [0.37–1.32] | 0.27 | 0.39 [0.19–0.80] | 0.01* |
| Prolonged EEAE vs. no EEAE | 1.25 [0.64–2.40] | 0.52 | 0.65 [0.30–1.41] | 0.28 |
| Prolonged EEAE vs. short EEAE | 1.78 [1.15–2.75] | 0.01 | 2.56 [1.25–5.26] | 0.03* |
| LOS, all pathogens | ||||
| Any EEAE vs. non-EEAE | 1.03 (0.71–1.50) | 0.88 | 0.78 (0.47–1.28) | 0.32 |
| Short EEAE vs. no EEAE | 1.02 (0.69–1.49) | 0.94 | 0.83 (0.50–1.38) | 0.47 |
| Prolonged EEAE vs. no EEAE | 1.07 (0.70–1.64) | 0.75 | 0.62 (0.35–1.10) | 0.10 |
| Prolonged EEAE vs. short EEAE | 1.43 (0.80–1.39) | 0.70 | 0.75 (0.35–1.07) | 0.11 |
| EEAE duration (days) | 0.97 (0.92–1.02) | 0.19 | 0.90 (0.85–0.97) | 0.003** |
95%CI 95% confidence interval, CoNS coagulase-negative staphylococci, EEAE early empiric antibiotic exposure, LOS late-onset sepsis, NEC necrotizing enterocolitis, OR odds ratio
*P < 0.05; **P < 0.01
aAdjusted for center, mode of delivery, gender, birth weight percentile, gestational age, Apgar score 5 min, days of parenteral feeding, invasive ventilation support, and/or inotropic medication use