Table 4.
The value of circulating long non-coding RNAs (lncRNAs) as non-invasive biomarkers for ischemic stroke (IS) diagnosis and prognosis.
| lncRNA | Sample | Regulation | Diagnostic value | Prognostic value | Specificity, % | Sensitivity, % | Area under the ROC curve (AUC) value | Reference |
|---|---|---|---|---|---|---|---|---|
| Nuclear enriched abundant transcript 1 (NEAT1) | Plasma | Up | Yes | Yes | 82.9 | 64.3 | 0.80 | [42] |
| ENST00000568297, ENST00000568243 and NR_046084 | Peripheral whole blood | Up | Yes | No | 80.0 (combined) | 82.8 (combined) | 0.84 (combined) | [43] |
| ANRIL | Plasma | Down | Yes | No | 71.2 | 72.2 | 0.76 | [44] |
| ZNFX1 antisense RNA 1 (ZFAS1) | Leukocytes (WBC) | Down | Yes | No | 48,6 | 89,3 | 0,727 | [45] |
| Myocardial infarction associated transcript (MIAT) | Leukocytes (WBC) | Up | Yes | Yes | 80,4 | 74,1 | 0,84 | [46] |
| Antisense non-coding RNA in the INK4 locus (ANRIL) | Serum | Up | Yes | No | 83,7 | 70,1 | 0,85 | [47] |