Figure 5.

Transcriptome analyses via RNA-sequencing reveal an upregulation of immune-related and lipid-metabolism–related pathways and biological processes in response to high fat diet. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways and gene ontology biological processes are depicted in the following dot plots: (A) downregulated KEGG pathways, (B) upregulated KEGG pathways, (C) downregulated biological processes, and (D) upregulated biological processes. C57BL/6J male mice consumed a control diet or an experimental high-fat diet (HFD) for 15 weeks. N = 7–8 mice per group. All depicted pathways and biological processes are significant based on differential gene expression (DeSeq) analysis with Benjamini-Hochberg p-adjusted < 0.1.