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. 2022 Sep 11;65:101598. doi: 10.1016/j.molmet.2022.101598

Figure 1.

Figure 1

MSDC-0602K is less detrimental than pioglitazone on bone parameters in obese mice. (A-E) μCT analysis of cortical and trabecular bone in L5 vertebrae in treated mice. Cortical and trabecular parameters were calculated as (A) cortical porosity (Ct.Po), (B) cortical thickness (Ct.Th) and (C) trabecular number (Tb.N). Data are presented as mean ± SEM (n = 4–7 per group); one-way ANOVA, Tukey's multiple comparison test, a: ND vs other groups, b: HFD vs other groups. (D) Representative pictures of 3D reconstructed μCT images from trabecular and (E) cortical bone analysis of L5 vertebrae with colorimetric scale of pore size (scale bar 0–0.1 mm). (F) Analysis of the ratio of circulating markers of bone resorption (P1NP) and bone formation (TRAP) in murine plasma samples after 8 weeks of dietary intervention. Data are presented as mean ± SEM (n = 6–10 per group); one-way ANOVA, Tukey's multiple comparison test, a: ND vs other groups. (G) Ultimate bone strength of femurs was evaluated as first point of the plateau of the load–displacement curve measured during three-point bending test. Data are presented as mean ± SEM (n = 10–11 per group); one-way ANOVA, Tukey's multiple comparison test, a: ND vs other groups, b: HFD vs other groups. Data are presented as mean ± SEM (n = 10–11 per group); one-way ANOVA, Tukey's multiple comparison test, a: ND vs other groups.